CYP4F2

The CYP4F2 is involved in the synthesis of a number of sterols and lipids. Because it was involved in the production of 20-hydroxyeicosatetraenoic acid (20-HETE), it was postulated to be involved in the pathophysiology of hypertension. It is now thought to be also involved in the breakdown of Vit K1. Correspondingly, the V433M variant is thought to result in decreased breakdown of VitK1 and an leading an excess of VitK1, leading to relative warfarin resistance. Recent studies have suggested that the polymorphism contributes 1-2% of the variability in warfarin dosage requirements.

The frequency of the polymorphism in Caucasians and 'Asians' is approximately 30%. There isn't any more specific population frequencies than these, and I have no breakdown of Chinese, Malay and Indian frequncies.