Pharmacogenetics isn't really a new science. The term was first coined by Friedrich Vogel back in 1959 when not many people were really interested. It was really only in relatively recent time, after genetic/genomic technologies became widely available that it had a renaisance. Now it's become somewhat of a hip and much hyped up science.
Newbies often get confused by the two terms 'pharmacogenetics' and 'pharmacogenomics', often abbreviated to PGt and PGx. The two terms have overlapping characteristics and PGt is often seen nowadays as being a subset of PGx. In fact the two terms have often been used interchangeably by various publications. But for those of us working in this areas, the distinctions can be quite distinct. For us, PGt is often a study of the variations in a targeted gene, or group of functionally related genes. PGx, on the other hand is a much broader investigation of genetic variations at the level of the genome.
Here are some definitions of these terms as given by the FDA and the NCBI.
FDA Guidance for Industry (2008) E15...
PGt: The study of variations in DNA sequence as related to drug response
PGx: The study of variations of DNA and RNA characteristics as related to drug response
NCBI Factsheet
PGt: The study of inherited differences (variation) in drug metabolism and response.
PGx: The general study of all of the many different genes that determine drug behavior.
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