“The things we hate about ourselves aren't more real than things we like about ourselves.” Ellen Goodman


Monday, January 8, 2018

Over-Atropinization

There was a time in Pharmacology, when acetylcholine was very topical, as were the effects of atropine. We studied the over-atropinization toxidrome by memorizing the idioms found in almost every textbookof Pharmacology : Hot as a hare, mad as a hatter, red as a beet, dry as a bone, blind as a bat..... I must confess these idioms didn't mean much to me as a student in Singapore. I just couldn't identify with them. Hot as a hare?? Mad as a hatter?? But memorize them we did, and made it through the exams.

Here is my contemporay remake of the idioms! Hot as a (hot) pot, Mad as (Mad) Max, Red as (Red) Sonja, Dry as (Mars), Blind as Dare Devil.

We don't see much over-atropinization nowadays, but it's worth remembering the toxidrome.

For completeness sake, the full toxidrome looks something like this:
Delirium
Drowsiness
Dilated pupils
Dry mouth
Dysphagia
Drunken gait
Dry, hot skin
Death

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