Visualizing the effects of body weight and clearance on the plasma concentration - time profile

Here is an interactive graph that helps you visualize how the volume of distribution (simplistically affected here by the body weight) and the clearance of a drug affect the plasma concentration - time profile of a drug that is orally administered 3 times a day (8 hourly).

Play around with the sliders provided and see how the profile changes. Note how the half-life changes as well as how the steady state plasma concentrations, area under the curve (AUC), minimum and maximum concentrations change. How about the time required to reach steady state? And how much accumulation occurs under the different situations?

Think about how individual profiles may vary because of differences in body weights and the ability of their bodies to clear specific drugs.

[No canvas support]

BW(kgs): 70       

Clearance: 9.1

Dose Interval = 8hrs,

Accumulation Index: 2.0       Halflife: 8.0